Objective :
To determine whether enlarged pituitary
gland is responsible for reversal of age into excellent
health.
Design:
A case study; correlation of the reports
with physical signs and symptoms
Tests conducted:
In addition to a complete medical history
and medical examination, diagnostic procedures for enlarged
pituitary may include:
- Measurement of hormone levels in the blood
- Magnetic resonance imaging (MRI) - a non-invasive
procedure that produces two- dimensional views of
an internal organ or structure, especially the brain
or spinal cord
Background
This is a case study of a healthy subject
who has an excellent health with a fully functioning
body and brain, a very high level of perception, interpretation
and execution of daily activities. But physiology point
of view his body does not correlate with any human on
this planet that makes him unique in nature.
His name is Mr. Mahendra Kumar Trivedi,
also known as "GURUJI", aging 44 years.
In Nov 1995 Guruji started experiencing
a series of changes in his physiology which is yet unexplainable.
To understand these continuous processes of changes,
Guruji underwent few investigations in AUSTRALIA, CANADA
and INDIA. These investigations revealed highly
unusual findings of his body which were baffling to
the concerned medical examiners.
After examining, absolutely healthy
musculoskeletal and cardiovascular system of Guruji,
panel of doctors were curious to know whether these
changes are possible with or without the interference
in the hormonal system.
So the master gland of the endocrine
system, "Pituitary gland", was decided to
be investigated, so GURUJI underwent for hormonal testing along with MRI
of brain and spine.
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Guruji's brain MRI Image |
On MRI examination, the size of Guruji's
pituitary fossa, also known as Sella tursica is found
to be 18.5 mm (anterioposterios) by 12.8 mm. in height,
which is the largest ever found in a healthy subject,
whereas in medical science it is a known fact that the
pituitary gland's size is not more than 5.5 to 7.5 mm
in diameter. In aging process, the size of the brain
starts shrinking, so the size of the pituitary gland
should not increase except in the cases of trauma or
diseases.
According to The National Institute
of Diabetes and Digestive and Kidney diseases, autopsy
studies indicates that 25 percent of the US population
has some form of small pituitary tumor. The vast majority
of these is benign and not considered clinically significant.
Only a very small number of people (about 14 in 100,000)
experience health effects attributable to pituitary
tumors.
It would be difficult to overstate
the influence of pituitary hormones over physiologic
processes. The target cells for most of the hormones
produced in these tissues are themselves endocrine cells
and a seemingly small initial signal are thus amplified
to cause widespread effects on many cells and tissues.
The focus here is to assess the role
of
(1) Few major hormones produced by pituitary gland
(2) Other enzymes, with significant emphasis on their
secretion and mode of action resulting in Guruji's unique
physiology.
The growth of the skeleton is governed
by a hormone produced in the pituitary gland, when this
growth hormone does not function normally, the effects
are easily recognized. Growth hormone stimulates growth in
childhood and is important for maintaining a healthy
body composition and well-being in adults. In adults
it is important for maintaining muscle mass as well
as bone mass. Growth hormone deficiency is associated
with an increased risk for heart disease
Age is the most important single risk
factor, with your risk increasing every year you live.
To keep bones strong, your body is always breaking down
old bone and replacing it with new bone tissue. As people
enter their forties and fifties, more bone is broken
down than is replaced. Normal aging is accompanied by a number
of catabolic effects, including a decrease in lean mass,
increase in fat mass, and decrease in bone density.
Associated with these physiologic changes is a clinical
picture often referred to as the somatopause: frailty,
muscle atrophy, relative obesity, increased frequency
of fractures and disordered sleep.
All these signs of aging mentioned
above are not observed in Guruji.
Major role of growth hormone in stimulating
body growth is to stimulate the liver and other tissues
to secrete IGF-I. IGF-I stimulates proliferation of
chondrocytes (cartilage cells), resulting in bone growth.
Growth hormone does seem to have a direct effect on
bone growth in stimulating differentiation of chondrocytes
that undergo differentiation resulting in bone growth. IGF-I also appears to be the key player
in muscle growth. It stimulates both the differentiation
and proliferation of myoblasts. It also stimulates amino
acid uptake and protein synthesis in muscle and other
tissues. The rate of growth hormone secretion
from the anterior pituitary is highest around puberty,
and declines progressively thereafter.
Comparing the musculoskeletal system
of Guruji with a young healthy subject around puberty,
Guruji should have growth hormone secretion within normal
range, but according to the lab reports (SRL RANBAXY
Clinical Reference Laboratories, Mumbai - INDIA ) growth hormone level was much lower than the value that can be measured by the technology. So how does Guruji have absolutely healthy musculoskeletal
system as mentioned above?
Spine
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Guruji's spine MRI Image |
Guruji's spinal column was examined
by Dr Patil, an Orthopedic Surgeon from Maharashtra,
INDIA and three independent Radiologists in November, 2004 and in July 2008. There are four factors present
in Guruji's spinal column that was never ever observed
and documented in the Medical history. Full spine X-rays
were taken with Guruji in the standing position and
were read by the experts. The most significant of these
factors is the age of the spinal column. Each doctor
concluded, independently, that the X-rays had full intervertebral
disc spaces, clear and smooth spinal joint surfaces,
and perfect spinal curves in the cervical, dorsal, lumbar
and lumbosacral areas. There were no soft tissue shadows
indicating that there was no swelling, toughness or
fibrosity in the surrounding muscles and soft tissues.
The density of the bones in Guruji's
spinal column was at the highest possible level.
The conclusion of each independent expert was that the
X-rays were consistent with those of a male 18 years
of age, who had completed growth plate fusion, but no
older than 25 years of age. After 25 years of age, deterioration
is observed in the joints, disc spaces, bone density
and surrounding soft tissue shadows due to the process
of imbibitions, the loss of water in joint cartilage
and intervertebral discs,
The curvatures of Guruji's spinal column
are in perfect alignment, his spinal curves all appeared
to be moving towardthe center of his body, they show the
perfect balance of lordosis (inward curve of the neck
and low back) and kyphosis (outward curve of the dorsal
spine and the sacrum).
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Guruji's spine MRI Image |
Guruji's paraspinal muscles, which
are more developed, broader and deeper (2-3 cm in depth)
than any top athlete in the world, are moving his spinal
bones into the center of his body. Even though Guruji's
muscles are so developed, he has more movement and flexibility
than a child.
The third point regarding Guruji's
spinal column is that his cervical spine (neck) is unique
in the areas where it meets his dorsal spine and where
it meets his skull. These areas show more movement,
fluidity and flexibility than any neck ever examined.
Guruji's breathing is abdominal, with
little chest movement i.e. very little or no movement
of the diaphragm; which is biomechanically impossible.
If there is no rib movement, Guruji's diaphragm is not
working as it does in all other humans, which leaves
us with the question of how he is getting enough oxygen?
If Growth Hormone LEVEL is low,
- then the symptoms given below do not match with Guruji.
Typical symptoms of growth hormone
deficiency
- Increase in adipose (fatty) tissue (especially around
the waist)
- Decrease in lean body mass (muscle)
- Decrease in strength and stamina, reduction in exercise
capacity
- Decrease in bone density, increase in rate of fracture
in middle age and beyond
- Changes in blood cholesterol concentrations (increase
in LDL and decrease in HDL)
- Excessive tiredness
- Anxiety and depression
- Feelings of social isolation
- Reduction in 'quality of life'
- Increased sensitivity to cold or heat
Growth hormone has important effects
on protein, lipid and carbohydrate metabolism
Carbohydrate metabolism: Growth
hormone is one of a battery of hormones that serves
to maintain blood glucose within a normal range. Growth
hormone is often said to have anti-insulin activity,
because it suppresses the abilities of insulin to stimulate
uptake of glucose in peripheral tissues and enhance
glucose synthesis in the liver.
The Glucose tolerance test [blood and
urine] was found positive in Guruji. Oral glucose tolerance
test (OGTT) value was greater than 260 mg/dl when measured
at a half an-hour interval for continuous 2 hrs.
So according to the test, Guruji should
either have Diabetes mellitus, non-insulin-dependent
diabetes mellitus (NIDDM) or insulin-dependent diabetes
mellitus (IDDM) also none of these symptoms are observed
in Guruji.
- Frequent infections that are not easily healed
- Frequent urination
- Extreme hunger but loss of weight
- Unusual thirst
- Blurred vision
- Extreme weakness and tiredness
- Irritability and mood changes
- Nausea and vomiting
- High levels of sugar in the blood when tested
- High levels of sugar in the urine when tested
- Dry, itchy skin
- Tingling or loss of feeling in the hands or feet
- Irritability and mood changes
Diabetes is a serious disease, which,
if not controlled, can be life threatening. It is often
associated with long-term complications that can affect
every system and part of the body. Diabetes can contribute
to the following conditions.
- Kidney failure
- Amputation
- Nerve damage
- Eye disorders and blindness
- Heart disease
- Stroke
Of the nearly 16 million Americans
with diabetes, 90-95 percent (15.3 million) has type-
2 diabetes.
Diabetes by itself is now regarded
as the strongest risk factor for heart disease. A variety
of mechanisms most likely come into play, however, in
addition to blood glucose levels. The blood vessels
in patients with diabetes are more susceptible to other
well-established risk factors, such as high cholesterol,
high LDL, blood pressure and aging.
A healthy heart is necessary to assure
that your tissues receive needed oxygen and nutrients
while removing waste products such as carbon dioxide.
As we age, the heart can be damaged by a number of processes.The heart's electrical system can wear out, and lead
one to require an artificial pacemaker. The contraction
and relaxing of the heart's muscular walls can decline,
leading to a condition known as congestive heart failure.
Additionally, the blood vessels (tubes) that supply
blood to the heart themselves can become partially or completely
clogged by atheromas / plaques resulting into coronary
artery disease.
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